Recombinant Human Il-23 (heterodimer) 10ug Expressed In Human Cells

US $49.99

Livermore, California, United States
Jul 10th

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Summer Promotion Recombinant Human IL-23 Product Specifications • Expression of Human Proteins in Human Cells • Extreme low Endotoxin • High Purity • Animal Free and Xeno Free • Tag Free Source: Human cells derived Structure: Glycosylated heterodimer Purity: >95% by SDS-PAGE Endotoxin Level: <0.5EU/ug Molecular Weight: 55kDa Formulation: Lyophilized from a 0.2m filtered solution in PBS without carrier protein Activity Assay The activity was measured by its ability to induce the IL-17 expression in murine splenocytes. Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution. Protein Description IL-23 is a heterodimeric cytokine composed of two subunits: a unique p19 subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T cells and promotes production of proinflammatory cytokines, such as IFN and IL-17. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. References Oppmann B, et al. (2000) Immunity 13,715-725. Lupardus PJ, et al. (2008) J. Mol. Biol. 382,931-941. Aggarwal S, et al. (2003) J. Biol. Chem. 278,1910.

Condition:	New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is applicable). Packaging should be the same as what is found in a retail store, unless the item was packaged by the manufacturer in non-retail packaging, such as an unprinted box or plastic bag. See the seller's listing for full details. ...	Custom Bundle	No
Common Name	HCT-I23-0010
Volume/Quantity	10ug
Brand	StemImmune LLC
MPN	HCT-I23-0010
Intended Use/Discipline	Anesthesiology, Biological Laboratory, Cardiology, Cosmetology, Dental Laboratory, Dentistry, Dermatology, Emergency Medicine, Endocrinology, Endodontics
UPC	4913263157403